Different configurations on power amp and woofers

My woofer tower has 6 unit of 12 inches 4 ohm woofers each channel
Currently I connect 3 of them in series and then connect 2 sets of them in parallel, the out come would be around 6 ohms , driven by one mono amplifier .
My question is any other configuration may have better performances overall , say 3 woofers in series but not connect 2 sets in parallel then use 2 monos to drive them separately
Or 2 woofers in series , then Sum up with 3 sets then drive them by 3 mono amps
Sorry for my bad English
Hope you understand what I just described :joy: