To potentially avoid a little confusion with the new Mk II software when using it’s automatic power off (on) of the I2S and USB inputs:
Note that if an active USB input is powered off your PC will see the USB device go away and you might see a new USB device show up which is the bootstrap USB device for the USB chip in the Mk II. Then when the USB port is powered back on the PC will see the Mk II USB again. When a USB audio device comes and goes there can be a lot of rearanging of input and output audio connections.
Most people who plan on using USB now and then should keep the USB powered up always.
Those who don’t use USB ever can set the USB to auto power up and if they then select USB as an input it will power up, but otherwise it will be quiet.