It is hard to believe … I was very skeptical, myself. How could changing out a fuse make a meaningful audible improvement? I switched directly from the DS Sr.'s stock fuse to the Audio Magic Beeswax SHD, and I have not tried any other aftermarket fuses, so please take my comments with a grain of salt. Other posters on this thread have tried several fuses in the DS, so they can compare various aftermarket fuses. In my case, I can only compare stock vs. AM, which could be something of a false comparison, i.e., the changes I hear could be as much or more about the REMOVAL of the stock fuse than the ADDITION of the AM fuse. In any event, I have yet to read a post stating that a DS Sr. fuse change did not make a difference.
In my system, the AM fuse caused an immediate impact on the sound. Right away, there was more detail across the tonal spectrum, but this additional detail came at the expense of a new stridency or edginess that was not worth the additional detail. Well, over the fuse burn-in period, the stridency/edginess subsided and the result was a more detailed yet tonally neutral sound, as well as a somewhat deeper and wider sound stage. My DS Sr. sounded great to begin with, so I want to be careful not to attribute too much to the fuse swap. I view the situation this way: The stock DS Sr. has the potential for even greater detail and an even deeper/wider sound stage, but the stock fuse is holding things back to a degree. In my system, removing the stock fuse and installing the AM fuse helped to better release the DS Sr.'s awesome potential.
Granted, $175 USD for a fuse is an obscene amount of money. But the incremental cost relative to the price of the DS Sr. is tiny. And in a way, installing the AM fuse can actually SAVE money, albeit indirectly. By way of example, prior to the fuse swap, I had been kicking around the idea of purchasing a DAC that retails for around fifty percent more than the DS Sr. Now I am content to sit tight with the DS Sr. for the foreseeable future.
Your mileage may vary, of course, but the fuse swap is reversible, and there is at least one online retailer that offers a thirty-day return policy. Hence, there is not much to lose by trying the swap. Just be sure to give the fuse 125-200 hours of DAC-powered-up time before reaching any conclusions. Oh, and opening up the “piano-top” DS Sr. is not that easy. Once you do, though, the fuse swap is a piece of cake.
Note: I have no financial interest in Audio Magic or the online retailer from which I bought the fuse.

