Elk said: Yet, as we all know, there is no reason for this to be the case based on the physical characteristics of the wires.
That's true, unless the physical characteristics are in fact different from wire to wire - metallurgy, geometry, dialectric, effective length, characteristics like propagation speed, capacitance, etc. If people consistently find a difference between cables of different physical characteristics it - at least in my opinion - somewhat deepens the mystery about why different cable construction might have an audible effect.
One thing that I've always found a bit troubling about ABX is that, on the one hand, if there is a difference people are appreciating it seems reasonable to suppose that ABX should be able to reveal it, and the results should be better than random. Blindingly obvious, one might say.
But there is another aspect to this which I think deserves consideration, which is whether ABX is the right kind of protocol for testing very subtle changes - changes that are much less like seeing a light flashing in your peripheral vision at the eye doctor, and much more like contemplating the whole picture. The difference is like what Paul was mentioning in a post a few months ago that he sometimes gets asked on the spot to deliver verdicts on systems when it actually takes him a while to get into the sound and actually get what the system is doing (or not doing).
So here's what I think the difference in practice might be - I am reasonably confident I could correctly ABX the last speaker cable I had and the one I currently have - with respect to some precise characteristics of how they sound in my system on some carefully selected recordings. (This is pretty erudite business - and we pay for it!) There were things previously unheard, or heard differently, that were pretty obvious. Indeed, this is actually not a case where expectation bias is at work, since I had no general or specific expectations, and attended to what might be different (this is, incidentally, a really old concept of 'disinterested appreciation' about which people have been arguing about in its modernist version since at least 1711.) But when it comes to much more nuanced qualities audiophools often prize - eg 'a sense of ease' or 'non-fatiguing over several hours of listening' 'liquidity' etc - I am not sure that ABX is of much use. Impracticalities associated with testing, limits of aural memory, etc. probably put the methodology out to pasture for some kinds of qualities that we appreciate.